Scientific Blogs

The latest developments of Medis QFR®

January 2023 edition

Written by Prof. Hans Reiber on January 12, 2022

Given the regular posts of peer-reviewed scientific publications on the developments of Medis QFR ®, it is clear that this angio-based solution for coronary physiology is extensively used in clinical research and practice. We would like to share these publications with you so that you remain up to date about the research that is ongoing worldwide with this innovative solution, whereby each time new clinical applications are being tested, validated and tried out in particular populations. With its non-invasive nature, readily available, and broad applicability, we anticipate a significant growth in its usage, supported by our constant quest for further automation.

In this new Medis QFR® blog, we are proud to share four publications on the latest developments of Medis QFR with you.

QFR is related to anatomic left main stem lesion parameters as assessed by intravascular imaging

Dr. A. Milzi and co-authors under the supervision of Dr. M. Burgmaier from the university hospitals in Aachen and Cologne, Germany published this interesting paper in the Journal of Clinical Medicine. In a retrospective data set of 53 patients with left main disease, the authors tested the association between anatomic assessment of the left main stem (LMS) using OCT (n=28) or IVUS (n=25) and the QFR functional assessment. They calculated the QFR of the left main (LMS) from analyses including the LAD and the Cx using the index QFR function. These values were averaged to obtain the LMS-QFR value. The results demonstrated that the QFR could predict a LMS-MLA < 6 mm2 with a high diagnostic accuracy (AuC 0.919) and < 4.5 mm2 with AuC = 0.798. In conclusion, the QFR might be a valuable tool to assess LMS disease.

For further read: click here

Coronary physiology at the cath lab

Dr. J.P. Vilchez-Tschischke from the university hospital in Valencia, Spain and co-authors from Spain and Mexico under the supervision of Dr. H.M. Garcia-Garcia at the Medstar Washington Hospital Center in the USA published this paper in REC Interventional Cardiology. It is a very nice up-date overview of coronary physiology in the cath lab from the traditional wire approaches for epicardial coronary obstructions to the index of microcirculatory disease, to the more recent angio-based approaches including the Medis QFR and the QFR-IMR.

For further read: click here

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Angiography derived assessment of the coronary microcirculation: is it ready for prime time?

Dr. J. Zhou and many co-authors under the supervision of Prof. Y. Onuma and Prof. P.W. Serruys at the National University of Ireland at Galway published this very nice overview paper. Non-obstructive coronary arteries (NOCA) are present in 39.7% to 62.4% of patients who undergo elective angiography. In this review the authors revisit the pathophysiology, clinical importance, and invasive assessment of the coronary microcirculation, and discuss angiography-derived indices of microvascular resistance, incl the Medis QFR-IMR.

For further read: click here

Functional patterns of coronary disease: diffuse, focal and serial lesions

Dr. R. Scarcini and co-authors under the supervision of Dr. F.L. Ribichini of the Division of Cardiology at the Verona University Hospital in Italy published in JACC Interventions an extensive state-of-the-art review about the available evidence on functional patterns of CAD with a special focus on the diagnostic and therapeutic implications. They provided a practical algorithm to optimize the use of pressure wire and angio-derived indexes of coronary physiology, incl. Medis QFR, and the QVP-index (QFR Virtual pullback) in the setting of focal, serial and diffuse lesions.

For further read: click here

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