Scientific Blogs

The latest developments of Medis QFR®

February 2023 edition

Written by Prof. Hans Reiber on February 2, 2023

Given the regular posts of peer-reviewed scientific publications on the developments of Medis QFR ®, it is clear that this angio-based solution for coronary physiology is extensively used in clinical research and practice. We would like to share these publications with you so that you remain up to date about the research that is ongoing worldwide with this innovative solution, whereby each time new clinical applications are being tested, validated and tried out in particular populations. With its non-invasive nature, readily available, and broad applicability, we anticipate a significant growth in its usage, supported by our constant quest for further automation.

In this new Medis QFR® blog, we are proud to share four publications on the latest developments of Medis QFR with you.

Outcomes of functionally complete versus incomplete revascularization. Insights from the FAVOR III China trial.

Dr. R. Zhang and coauthors from the FAVOR III China Study Group under the leadership of Dr. G. Stone published the results of the study in JACC Interventions. In this substudy of the FAVOR III China prospective outcome trial, the authors investigated the clinical implications of functional complete revascularization (FCR) in the QFR-guided and angiography-guided groups based on core-laboratory-assessed QFR and the calculation of the residual functional SYNTAX-score. 88.1 % of the QFR-guidance group and 82.2% of the angio-guided group achieved full revascularization (p< 0.001). Patients with FCR had a markedly lower rate of 1-year MACE compared with those with functional incomplete revascularization. The authors concluded that QFR-guided PCI lesion selection as compared to angiography guidance, improved the likelihood of achieving FCR and improved 1-year clinical outcome in patients with both complete and incomplete revascularization.

For further read: click here

QFR facilitated function lesion assessment to guide revascularization. The Next Paradigm Shift? Editorial Comment.

Dr. T.D. Henry and Dr. D.J. Kereiakes from the Christ Hospital in Cincinnati, Ohio wrote an Editorial Comment in JACC Interventions. In this Editorial Comment the authors comment on the intriguing results of the substudy of the FAVOR III China regarding the complete or incomplete revascularization results by Zhang R et al, the opportunities, the challenges, and the prospect of more physiologically “precise” PCI treatment in routine clinical practice.

For further read: click here

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Prevalence of psychoactive drug use in patients hospitalized for acute coronary events: Rationale and design of the ADDICT-ICCU trial

Dr. J.G. Dillinger and the investigators of the ADDICT-ICCU trial under the supervision of Dr. P. Henry from Hospital Lariboisiere in Paris, France published this paper in the Archives of Cardiovascular Disease. The paper describes the Rationale and design of the ADDICT-ICCU trial, which is a nationwide prospective multicentre study, involving 39 centers in France, including all consecutive patients hospitalized in an intensive care unit within 2 weeks. In this trial the prevalence of psychoactive drug use will be assessed in patients hospitalized for acute cardiac events. The angiographic core lab will analyze the  coronary angiograms with the Medis QFR and the QFR-IMR for non-invasive index of microvascular resistance.

For further read: click here

Coronary microvascular dysfunction as assessed by angiography-derived index of microvascular resistance co-localizes with and may explain the presence of ischemia in stress-cardiac magnetic resonance imaging in the absence of coronary artery disease.

Dr. Milzi and co-authors from the University hospital in Aachen, Germany under the supervision of Dr. Burgmaier published this paper in Frontiers in Cardiovascular Medicine. This is a retrospective study with the goal to investigate the association of single vessel angio-derived index of microvascular resistance by Medis QFR-IMR with areas of INOCA by stress-MRI. A total of 286 vessels from 102 patients were included. They found that INOCA patients presented higher mean QFR-IMR compared to both CAD patients and controls. Also, single vessel QFR-IMR presented a very good diagnostic efficiency in detecting INOCA (AuC=0.865) with a cut-off value of 27.1.

For further read: click here

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