During-PCI: QFR-guided PCI approach improves long term clinical outcomes

Conducted at 26 hospitals in China, the study involved patients with coronary artery disease and lesions of 50-90% diameter stenosis. Participants were randomized to either a QFR-guided strategy (PCI performed only if QFR ≤0.80) or an angiography-guided strategy. The results demonstrated that the QFR-guided group exhibited a lower incidence of major adverse cardiac events (MACE) at 2 years compared to the angiography-guided group, driven by fewer myocardial infarctions and ischemia-driven revascularizations. Notably, the benefits of QFR guidance persisted over the 2-year follow-up period, particularly among patients in whom QFR assessment influenced the planned revascularization strategy. This study underscores the clinical utility of QFR in improving patient outcomes and optimizing PCI decision-making in routine practice.