During-PCI: QFR-guided PCI approach improves long term clinical outcomes

Reading time: 3 mins
Written on: March 19, 2024
In the FAVOR III China trial, we investigated whether utilizing quantitative flow ratio (QFR) guidance in lesion selection for percutaneous coronary intervention (PCI) could improve clinical outcomes compared to standard angiography guidance.
Conducted at 26 hospitals in China, the study involved patients with coronary artery disease and lesions of 50-90% diameter stenosis. Participants were randomized to either a QFR-guided strategy (PCI performed only if QFR ≤0.80) or an angiography-guided strategy. The results demonstrated that the QFR-guided group exhibited a lower incidence of major adverse cardiac events (MACE) at 2 years compared to the angiography-guided group, driven by fewer myocardial infarctions and ischemia-driven revascularizations. Notably, the benefits of QFR guidance persisted over the 2-year follow-up period, particularly among patients in whom QFR assessment influenced the planned revascularization strategy. This study underscores the clinical utility of QFR in improving patient outcomes and optimizing PCI decision-making in routine practice.

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