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Clinical evidence

Reference Values for Inward Displacement in the Normal Left Ventricle: A Novel Method of Regional Left Ventricular Function Assessment

Romy Hegeman – Amsterdam UMC

Regional functional left ventricular (LV) assessment using current imaging techniques remains limited. Inward displacement (InD) has been developed as a novel technique to assess regional LV function via measurement of the regional displacement of the LV endocardial border across each of the 17 LV segments. This study provides clinically meaningful reference ranges for InD in subjects with normal LV function, which will emerge as an important screening and assessment imaging tool for a range of HFrEF therapies.

Want to learn more? Read the article here: Reference Values for Inward Displacement in the Normal Left Ventricle: A Novel Method of Regional Left Ventricular Function Assessment

Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension

Alistair Macdonald – Sheffield Teaching Hospitals

Right ventricle (RV) mass
is an imaging biomarker of mean pulmonary artery pressure (MPAP) and pulmonary
vascular resistance (PVR). Using a semi-automated thresholding technique, the inclusion of trabecular mass and indexing RV mass for LV mass, improves the diagnostic accuracy of CMR
measurements in suspected pulmonary hypertension. Furthermore, the
semi-automated method significantly reduces the
time to obtain RV mass.

Want to learn more? Read the article here: Semi-automatic thresholding of RV trabeculation improves repeatability and diagnostic value in suspected pulmonary hypertension – PubMed

Association between left atrial myopathy and sarcomere mutation in patients with hypertrophic cardiomyopathy: insights into left atrial strain by MRI feature tracking

Jiaxin wang – Fuwai Hospital

Left atrial (LA) myopathy, characterized by LA
enlargement and mechanical dysfunction, is associated with a worse prognosis in hypertrophic cardiomyopathy (HCM) while the impact of sarcomere mutation on LA myopathy remains unclear. The study aimed to assess the association between LA myopathy and sarcomere mutation and to explore the incremental utility of LA strain in mutation prediction. In HCM, mutation-positive patients suffered worse LA enlargement and worse reservoir and booster-pump functions. LA booster-pump strain was a strong factor for sarcomere mutation prediction.

Want to learn more? Read the article here: Association between left atrial myopathy and sarcomere mutation in patients with hypertrophic cardiomyopathy: insights into left atrial strain by MRI feature tracking – PubMed

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