Dr. A. Erriguez and co-authors from the FIRE Trial under the guidance of Dr. Simone Biscaglia, Ferrara University Medical Center in Italy, published this exciting paper in JACC Interventions on the same day that the results were presented in a HotLine Session at the EuroPCI congress 2024 in Paris. This is a prespecified subanalysis (QFiRe study) of the FIRE trial, which randomized older MI patients to culprit-only or physiology-guided complete revascularization. QFR was measured on 903 nonculprit vessels from 685 patients in the culprit-only arm. 40.5% of non-culprit vessels showed a QFR ≤ 0.80, which emerged as an independent predictor of VOCE. In the complete arm, QFR was used in 320 vessels (35.2%) non-culprit vessels to guide revascularization. When compared with propensity-matched non-culprit vessels in which treatment was guided by wire-based functional assessment, no significant difference was observed. The authors concluded that this subanalysis provides evidence supporting the safety and efficacy of QFR-guided interventions for the treatment of nonculprit vessels in MI patients.