Understand the forces driving cardiac function with Hemodynamic Forces, a non-invasive way to quantify intraventricular pressure gradients from routine MR and ultrasound images.
*Hemodynamic Forces is for research use only and cannot be used in daily clinical practice for patient diagnosis and treatment.
For decades, cardiac function has been defined by volumetrics, primarily ejection fraction.
But cardiac function is more than volume alone.
Blood flow is driven by pressure gradients, shaped by myocardial motion, and influenced by ventricular mechanics.
To truly understand cardiac function, you need to measure Hemodynamic Forces.
Each heartbeat creates pressure differences inside the ventricle that drive blood flow. These are known as intraventricular pressure gradients.
Hemodynamic Forces represent the global effect of these gradients across the entire ventricle.
Hemodynamic Forces add a new dimension to cardiac assessment:
• Efficiency of ventricular filling and ejection
• Direction and magnitude of forces driving blood flow
• Interaction between myocardial motion and intracardiac flow
This adds a functional layer to cardiac assessment, complementing volumetrics and strain.
Derived directly from routine MR, CT or ultrasound images, no additional scans required.
Simple workflow:
1. Acquire standard MR, CT or ultrasound cine images
2. Automatic AI-based contouring*
3. Endocardial motion tracking
4. Biomechanical modeling
5. Results visualized as force vectors and quantitative metrics
* Note: Only available for MR images.
Historically, assessing pressure gradients required invasive catheterization or complex imaging techniques.
Medis makes Hemodynamic Forces accessible in daily practice:
• No additional scans
• No contrast agents
• Based on standard long-axis views
• Integrated into existing workflows
Hemodynamic Forces have shown promising value across multiple clinical scenarios:
• LV HDF may significantly improve the detection of early myocardial systolic dysfunction when volumetric and deformation cardiac measures are still intact.
• Assessment of HDF indicates impairment of LV systolic ejection force in HFpEF, which is associated with cardiovascular events
• Misalignment of diastolic HDF after STEMI is associated with adverse LV remodeling after 4 months
• CMR-derived LV IVPG are univariably associated with MACE. However, LV IVPGs do not add prognostic value to LV ejection fraction and LV GLS
• Dilated Cardiomyopathies: in the absence of pressure reversal, lower systolic ejection force, E-wave decelerative force, and overall LV IVPG are powerful predictors of outcome, independent of clinical and imaging parameters
• Analyzing both longitudinal and transversal HDF throughout the cardiac cycle enables the identification of distinct phenotypes with prognostic value beyond EF and LGE in non-ischemic LV cardiomyopathy
• Despite no further significant decline in LVEF and GLS after 3 months of anthracycline therapy, HDF continueto decrease, reflecting subtle changes in LV preceding overt functional impairment
• Higher sensitivity of HDFs as biomarkers of cardiotoxicity of cancer-related therapy
*Hemodynamic Forces is for research use only and cannot be used in daily clinical practice for patient diagnosis and treatment.
“We aim through research to better understand the underlying disease causes which can improve diagnosis or treatment in the end. With the HDF module of Medis, we have looked at patients with precapillary pulmonary hypertension to see if this parameter can help in the detection of subtle changes in the LV mechanics, which seems to be the case. This result makes us continue to further research the value of HDF.”
Prof. Robin Nijveldt, Cardiologist
Bring Hemodynamic Forces analysis into your daily workflow.
Medis Suite MR – Research Applications
Heart function is about creating and sustaining blood motion. This is achieved through a sequence of contraction-relaxation in the myocardial muscle which creates a pressure gradient across the ventricle also denoted as hemodynamic forces (HDF), which allows blood flow. HDF can enable clinicians to detect mechanical abnormalities earlier compared with conventional ejection fraction and strain analysis, and possibly predict the development of cardiac remodeling.
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